Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression

Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical with critical roles in many biological processes, including gene transcription, ribosome synthesis, cell metabolism, proliferation and apoptosis, DNA damage responses, genome stability. Furthermore, hCINAP/AK6 dysfunction associated cancer various inflammatory diseases. In this review, we summarize the structural features of hCINAP several important signaling pathways, well its connection tumor onset progression.